Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents
نویسندگان
چکیده
منابع مشابه
Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents.
Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein disulfide isomerase (PDI) is an oxidoreductase that has recently been shown to participate in thrombus formation. While currently available antithrombotic agents inhibit either platelet aggregation or fibrin generati...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2012
ISSN: 0021-9738
DOI: 10.1172/jci61228